Int Poster J Dent Oral Med 2011, Vol 13 No 2, Poster 537
A new life from the dead end ...
Dr Smriti Goswami, PG student, Dr Manisha Sharma, PG student, Prof. Dr Umesh Chandra Prasad G, Dr Pankaj Agrawal, Dr Ram Ballabh Upadhyay,
KD Dental college, BR Ambedkar University, Department of oral & maxillofacial pathology, Chattikara, Mathura ( U.P.), India
27th-29th November 2009
XVIIIth National Conference of Indian Association of Oral and Maxillofacial Pathologist
Indian habitat centre, New Delhi
The harm that tobacco use does to health is irrefutable. The evidence of careful scientific articles testifies that its use, smoke or smokeless and inhaling side stream smoke from cigarettes increases risk of many serious diseases particularly ORAL CANCER. However tobacco use is one of the major preventable causes of disease and premature death. In an ironic twist to the relationship between tobacco and human health, it would seem that the future of the tobacco plant may lie in growing vaccines against cancer. It is observed that the vaccine derived from tobacco plant can be used for treatment of various cancers like lymphoma, epidemic infections like norovirus infection, and as therapy against tobacco addiction.
|Fig. 1: tobacco plant
|Fig. 2: tobacco plant
Material and Methods
Searched the articles of pub med, Advances in Dental Research, medline (Sep 1997 - March 2011) for researches, reviews, clinical trials. Main search involved mesh terms associated with for tobacco effects and tobacco vaccines. Additional search involved systemic effects of tobacco, effectiveness of vaccine against addiction as well as relevant searching of references of all retrieved articles for possible inclusion.
Tobacco is available in various forms : Tobacco powder, cigar, cigrattes.Use in various forms have resulted many harmful effects like Oral cancer, addiction, infections.On the other hand tobacco plant itself yields many beneficial effects : Cancer vaccine, vaccine against addiction, vaccine against infection. many clnical trials have been done, still more to do.
Tobacco is available in various forms. Use in various forms have resulted many harmful effects:
Exposure to smokeless tobacco results in loss of anti-inflammatory activity of anoxein I and upregulation of proinflammatory cox 2 in oral cells, and this dual effects leads the cells down the carcinogenic activity.
Nicotine is a stimulant and one of the major cause of addiction, nicotine doesn't appear to present as a direct carcinogen activity itself but it enables the formation of tobacco specific nitrosamines which are potent carcinogens.
Carbon mono oxide tyramide causes pulmonary damage and loss of elasticity in alveoli leading to COPD and emphysema.
Various other systemic effects are also present. On the other hand tobacco plant itself yields many beneficial effects:
These are protein based tumour specific vaccine, cheap carry low risk to pt and work as Ab chemical specific to tumour cells.
Vaccine against addiction
Derived from nicotine containing hapten carrier conjugate as a result nicotine reaching brain decreases to 64%.
Vaccine against infection
Tobacco derived antigen prompted an immune response that was 4-20 times higher than that from other engineered antigen. Clinical trials in mice have been successful for vaccine against norovirus infection.
Other uses in different disorders: Parkinson's disease, Tourtte's disease, Alzhimer's disease, ulcerative colitis, sleep apnea.
|Fig. 3: oral cancer
||Fig. 4: addiction
|Fig. 5: addiction of smoke
||Fig. 6: vaccine against infection
|Fig. 7: form of tobacco - cigar
||Fig. 8: dead end
|Fig. 9: infections - TB Pt
||Fig. 10: vaccine against infection
Tobacco use is one of the major preventable cause of disease and premature death. The same plant which is responsible for causing cancer may offer a way to treat the disease. However, government still hesitate to act progressively to reduce tobacco use as it may affect the economic benefits that a country derives from growing, processing, manufacturing, exporting and taxing tobacco.
- N. L. Benowitz, Systemic Absorption and Effects of Nicotine from Smokeless Tobacco, Adv Dent Res 11(3)336-340, September, 1997.
- Nicotine conjugate vaccine: is there a right to a smoking future? A Hasman, Søren Holm, J Med Ethics 2004;30:344-345
- Good and Evil: A Cancer Vaccine from Tobacco Plants, July 22, 2008, Scientific American.
- David Biello , Tobacco Plant Transformed Into Plague Vaccine Factory, Scientific journal, January 10, 2006.
- Graeme Stemp-Morlock ,PLANT vs. PATHOGEN: Enlisting Tobacco in the Fight Against Anthrax , Environ Health Perspect. 2006 June; 114(6): A364-A367.
- Jacques Cornuz et al, Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial, PLoS ONE. 2008; 3(6): e254
- Alison A. McCormick, Tobacco derived cancer vaccines for non-Hodgkin's lymphoma: Perspectives and progress, Volume 7, Issue 3, March 2011, Pages 305 - 312, human vaccines.
This Poster was submitted by Dr Smriti Goswami.
Dr Smriti Goswami
BR Ambedkar University
Department of oral & maxillofacial pathology
KD Dental college NH-2
Chattikara, Mathura ( U.P.) 281001