Wir verwenden Cookies, um für diese Website Funktionen wie z.B. Login, einen Warenkorb oder die Sprachwahl zu ermöglichen und für anonymisierte, statistische Auswertungen der Nutzung. Mehr Informationen finden Sie in unserer Datenschutzerklärung. Mit der weiteren Nutzung unserer Website erklären Sie sich damit einverstanden. Ja, ich bin einverstanden
International Poster Journal of Dentistry and Oral Medicine



Kennwort vergessen?


Int Poster J Dent Oral Med 19 (2017), OMD/PDA     15. Jan. 2018
Best investigation poster Int Poster J Dent Oral Med 19 (2017), OMD/PDA  (15.01.2018)

Supplement, Poster 1156, Sprache: Englisch

Minocycline-releasing PMMA for craniofacial bone reconstruction
In vitro characterization
Silva, Tiago / Grenho, Liliana / Barros, Joana / Silva, José / Pinto, Rosana / Colaço, Bruno / Fernandes, Helena / Bettencourt, Ana / Gomes, Pedro
Introduction: Craniofacial traumatic lesions frequently lead to debilitating and challenging consequences, as a result of infectious processes which make the immediate and successful surgical regenerative treatment difficult and/or impossible.
Objectives: In the present work, it is aimed the development and biological characterization of a poly methyl methacrylate (PMMA)-based minocycline delivery system, to be used as a space maintainer within craniofacial staged regenerative interventions.
Materials and methods: Developed PMMA systems were characterized regarding solid state characteristics and assayed in vitro for anti-bacterial and anti-inflammatory activity, and cytocompatibility with human bone cells.
Results: Drug release profile revealed the maintenance of minimum inhibitory concentrations against Staphylococcus aureus, slime-producer-S. epidermidis and Escherichia coli, up to 72 hours. Further, controlled minocycline release decreased the release of pro-inflammatory mediators from activated macrophages and enhanced the functionality of osteoblastic cells, within in vitro models.
Discussion: PMMA-based minocycline delivery system allowed for an adequate drug release profile, supporting a sustained antibacterial activity against relevant pathogenic bacteria commonly associated with craniofacial bone infections. Further, a sustained anti-inflammatory activity and enhanced bone cell response were verified.
Conclusions: The developed PMMA systems, with controlled release of minocycline, allowed for an effective antibacterial activity and enhanced cytocompatibility, supporting a prospective utility for staged craniofacial reconstructive approaches.
Clinical implications: The developed PMMA system displays an effective antibacterial activity and expectedly primes tissue healing through inflammation modulation and enhancement of osteoblastic response.
Funding: This work was partly supported by the FCT grant UID/DTP/04138/2013.

Schlagwörter: minocycline, bone, PMMA, drug delivery system, biological characterization and cytocompatibility

Poster Award: Best investigation poster

26th Annual Meeting of the Portuguese Dental Association 2017 (OMD)
16.-18. November 2017
Altice Arena, Lisbon, Portugal