Int Poster J Dent Oral Med 17 (2015), No. 4 15. Dec. 2015
Int Poster J Dent Oral Med 17 (2015), No. 4 (15.12.2015)
Poster 930, Language: English
Are Genetic Variants of C-Reactive Protein Prognostic Markers for Further Cardiovascular Events in Patients with Coronary Heart Disease?
Schulz, Susanne / Lüdike, Henriette / Schlitt, Axel / Werdan, Karl / Hofmann, Britt / Gläser, Christiane / Schaller, Hans-Günter / Reichert, Stefan
Background: Periodontitis and coronary heart disease are both triggered by inflammatory reaction which is influenced by the genetic predisposition. C-reactive protein (CRP) plays an important role in inflammation and its expression is, among others, genetically controlled. Two CRP SNPs (rs1800947, rs1417938) are shown to be associated with different gene expression. One aim of this longitudinal cohort study (ClinicalTrials.govIdentifier: NCT01045070) was the evaluation of the prognostic importance of these CRP variants for further cardiovascular events in in-patients with coronary heart disease (CHD).
Patients and methods: At baseline a total of 940 consecutive patients with angio¬graphically proven CHD of the Martin-Luther-University Halle-Wittenberg (Germany), Department of Medicine III, were prospectively included in the study. The one-year cardiovascular outcome of the patients was evaluated considering the 98 predefined, combined, primary endpoint (cardiovascular death, myocardial infarction, and stroke/TIA (transient ischemic attack)).
Results: All 940 CHD patients completed the one-year follow up. 7.2% of the patients achieved the primary endpoint (myocardial infarction: 2.0%, stroke/TIA: 1.7%, cardiovascular death: 3.5%). In Kaplan-Meier survival curves and the log-rank tests, the genotype-, allele- and haplotype constellation of the CRP-polymorphisms rs1800947 and rs1417938 could not be proven as significant predictors for adverse cardiovascular events regarding the one-year outcome. Diabetes mellitus (Hazard ratio 1.79) and low body mass index (Hazard ratio 0.94) were confirmed to be prognostic markers for the predefined cardiovascular endpoint in cox regression analyses.
Conclusions: Genetic variants of CRP gene, rs1800947, rs1417938, could not be regarded as prognostic markers for further cardiovascular events among in-patients with CHD.
Keywords: cardiovascular disease, periodontitis, C-reactive protein, genetic
26. Jahrestagung der Deutschen Gesellschaft für Humangenetik
15.-17. April 2015