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International Poster Journal of Dentistry and Oral Medicine
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Int Poster J Dent Oral Med 16 (2014), No. 1     15. Mar. 2014
Int Poster J Dent Oral Med 16 (2014), No. 1  (15.03.2014)

Poster 739, Language: German/English


Single Nucleotide Polymorphismen (SNP) des VEGF-Gens beeinflussen die Langzeitprognose oraler Plattenepithelkarzinome
Single Nucleotide Polymorphisms (SNP) of the VEGF-gene influence long-term prognosis of oral squamous cell carcinoma

Kämmerer, Peer W. / Koch, Felix P. / Schiegnitz, Eik / Berres, Manfred / Al-Nawas, Bilal / Brieger, Jürgen
Einleitung: VEGF-SNPs sind mit der Inzidenz oraler Plattenepithelkarzinome (PECA) assoziiert. Ihr Einfluss auf die Prognose bei PECA-Patienten ist nicht nachgewiesen. Daher war es das Ziel dieser klinischen Studie, Korrelationen zwischen der Ausprägung der VEGF-Mutationen und prognostischen Langzeitfaktoren zu untersuchen.
Materialien und Methoden: Bei 120 PECA-Patienten, die kurative Tumorresektionen erhalten hatten, wurde die jeweilige Ausprägung von 5 VEGF-SNPs (-1154 G/A, +405 G/C, +936 C/T, -2578 C/A and -460 C/T) mittels RT-PCR untersucht. Diese Daten wurden mit klinischen Daten und der PECA-Prognose (Rezidiv, Zweit-Tumor, Metastasen, Tod, Disease-free-survival) verglichen.
Ergebnisse:
Nach einer mittleren Nachbeobachtungszeit von 58 Monaten zeigten sich:
32 Rezidive,
15 Zweittumore,
15 Metastasen und
23 Patienten starben.
Das Disease-free-survival betrug 43 Monate.

PECA-Patienten mit Nikotinabusus trugen signifikant häufiger die Mutationen -2578 A/C und -460 C/T (beide pT2/N>0) mit dem -1154 A/A- und der +405 G/G-SNP ein signifikant verschlechtertes Überleben und Disease-free-survival (alle p

INTRODUCTION: VEGF-SNPs are associated with the incidence of oral squamous cell carcinoma (OSCC). An impact of VEGF-SNPs on prognosis of OSCC patients has not been proven. Therefore, correlations between prognostic parameters of OSCC patients and f VEGF-SNPs were determined.
MATERIALS AND METHODS: In a retrospective long- term study, in 120 OSCC patients that underwent curative resections, five VEGF-SNPs (1154 G/A, +405 G/C, +936 C/T, 2578 C/A, and 460 C/T) were analyzed. Associations between SNPs and prognosis (incidence of local recurrent disease, second cancer, metastases, death, total disease-free survival) were examined.
RESULTS: After a mean follow-up time of 57.6 months, 32 patients had local recurrences; 15 patients had second cancer, 15 patients metastases, and 23 patients died. The mean disease-free survival was 43 months. A significant increased incidence of OSCC in smokers with the VEGF 2578 A/C and 460 C/T SNP was seen (each P < 0.015). In univariate analysis, patients with advanced OSCCs (T > 2 or N > 0) together with the 1154 A/A allele had a significant worse survival and a worse disease- free survival (both P < 0.04). The same was seen for the +405 G/G SNP (both P = 0.002). In multivariate analysis, only the negative influence of the +405 G/G SNP on survival in advanced OSCCs (T > 2) could be confirmed (P = 0.002).
DISCUSSION: Possible reciprocal interactions between smoking and VEGF-SNP function were observed. Multi- variate analysis confirmed the VEGF +405 G/G genotype to be associated with poor survival in advanced OSCCs; a further use of this haplotype as biomarker has to be discussed.

Keywords: Oral Squamous Cell Carcinoma, VEGF Mutation, Single Nucleotide Polymorphisms, Long-term Prognosis
Oral Squamous Cell Carcinoma, VEGF Mutation, Single Nucleotide Polymorphisms, Long-term Prognosis


Conference/Exhibition:
AGKi 2013
9th-10th May 2013
Bad Homburg, Germany