We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
International Poster Journal of Dentistry and Oral Medicine



Forgotten password?


Int Poster J Dent Oral Med 15 (2013), Osteology     30. June 2013
Int Poster J Dent Oral Med 15 (2013), Osteology  (30.06.2013)

Supplement, Poster 697, Language: English

Influence of a Collagen Membrane and rhPDGF on Early Bone Formation after Vertical Augmentation with Bovine Bone in Rabbits
Kämmerer, Peer W. / Palarie, Victor / Schiegnitz, Eik / Alshihri, Abdulmonem / Al-Nawas, Bilal
Introduction: Combination of bone substitute materials with growth factors may enhance prognosis of vertical bone augmentations (VBA). The aim of the study was an evaluation of the effect of a collagen membrane (Bio-Gide, Geistlich, Wolhusen, Switzerland) and a signal protein (rhPDGF, Sigma, St. Louis, USA) on VBA together with an implant-fixed bovine bone block (DBB; Bio-Oss, Geistlich, Wolhusen, Switzerland) in a rabbit animal model.
Materials and Methods: In 16 rabbits, a DBB-block was implant fixed on the tibia in a split-leg design (figure 1). The groups were:
1. DBB only (control; n=8),
2. DBB+collagen membrane (test; n=8),
3. DBB+rhPDGF (test; n=8) and
4. DBB+collagen membrane+rhPDGF (test; n=8).
Prior operation as well as 1h, 24h, 72h, 7d, 2 weeks and 3 weeks after operation, blood samples were taken and evaluated for alcalic and acid phosphatase (ALP, AP). Histomorphometric evaluation for new bone area (NBA; %)) and new vertical bone height (VBH; mm) was conducted after 3 (n=16) and 6 weeks (n=16).
Results: ALP and AP were significant higher in the membrane-groups after 1h and 72h (all p<0.05). After 7d, values were similar in all groups and after 2 and 3 weeks, the values in the groups without membranes were significant elevated (all p<0.05; exemplary figure 2). Histological analysis revealed no significant differences after 3 weeks. After 6 weeks, NBA and VBH were significantly elevated in the membrane groups (both p<0.01). rhPDGF (additional and alone) showed a non-significant early increase of bone metabolism and formation only.
Discussion: In vertical bone augmentation , the use of a collagen membrane led to an initially increased bone turnover manifesting in increased bone formation in a later phase of healing. Early rhPDGF-effects were seen for both bone metabolism and bone formation but turned out to be non-significant.

Keywords: Vertical Bone Augmentation, Xenogenic Bone Substitute, Collagen Membrane, rhPDGF

International Osteology Symposium 2013
May 2-4, 2013
Grimaldi Forum, Monaco