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Int Poster J Dent Oral Med 10 (2008), No. 1     15. Mar. 2008

Int Poster J Dent Oral Med 2008, Vol 10 No 01, Poster 395

Histomorphometry of bone augmentations with Bio-Oss®: A systematic review and meta-analysis

Language: English

Authors:
Dr. Dominikus Lysek, Bettina Ley MSc, Dr. Kay Horsch, PD Dr. Christoph Görlach
Geistlich Pharma AG, Wolhusen, Switzerland

Date/Event/Venue:
10.-12.05.2007
International Osteology Symposium
Monaco

Results

Figure 2: (A) Showing the variation in the newly formed bone with time. The specimen resulting from ridge augmentation (Blue) were compared to sinus floor augmentations (grey); (B) T-test for the variation between alveolar ridge and sinus floor augmentations for each time point. Statistically significant values (p<0.05) showing more bone formation in alveolar ridge augmentations are marked in green, statistical trends (0.10>p>0.05) in yellow.
Figure 1: (A) Variation of newly formed bone with time. The specimen in which only Bio-Oss® (Blue) was used were compared to sites treated with Bio-Oss® mixed with autogenous bone (grey); (B) p-Values of the t-test, performed for the variation between Bio-Oss® and Bio-Oss® mixed with autogenous bone. Statistical significance (p<0.05) showing a superiority for the addition of autogenous bone (green), or a trends (0.10>p>0.05) (yellow). Statistical significance showing superiority for pure Bio-Oss® (red), statistical trends (orange). (C) p-Values of the t-test performed for the difference of newly formed bone between the different time points for 100% Bio-Oss® (top) and (D) Bio-Oss® mixed with autogenous bone (bottom).

Figure 3: (A) Showing the variation in the newly formed bone with time. The specimen resulting from sinus grafting with 100% Bio-Oss® (Blue) and Bio-Oss® mixed with autogneous bone (B) T-test for the variation between 100% Bio-Oss® and Bio-Oss® mixed with autogenous bone for each time point. Statistical analysis showing more bone formation in for the addition of autogenous bone (green; p<0.05), statistical trends (0.10>p>0.05) yellow. Figure 4: (A) Showing the variation in the newly formed bone with time. The specimen resulting from ridge augmentations with 100% Bio-Oss® (Blue) and Bio-Oss® mixed with autogneous bone (B) T-test for the variation between 100% Bio-Oss® and Bio-Oss® mixed with autogenous bone for each time point. Statistical analysis showing a statistical trends for more bone formation for Bio-Oss® mixed with autogenous bone (0.10>p>0.05; yellow). the ones favouring 100% Bio-Oss® are underlain in orange.

Figure 5: (A) Showing the differences in the amount of newly formed bone in dependence of the age of the patient. (B) T-test for the variation of the amount of newly formed bone between the different age groups. Statistical significance (p<0.05) showing a superiority are underlaid in green, statistical trends values (0.10>p>0.05) in yellow. (C) T-test for the variation in the healing time between the different group. Statistical significant baseline variations are underlaid in green, and trends in yellow.

Figure 6: (A) Showing the differences in the amount of newly formed bone in dependence of the gender of the patients. The values are virtually identical. Figure 7: Showing the differences in the amount of newly formed bone in dependence of the fact if the patient is a smoker. The values are virtually identical.

Conclusions

The here presented data show that there is a significant difference in the kinetics of new bone formation when comparing different indication in implantology. Generally, new bone formation is slower in the maxillary sinus than for a ridge augmentation after grafting. Furthermore, the data show that for sinus grafting, the addition of autogenous bone to Bio-Oss® increases the amount of new bone formation up to 12 months after the surgical procedure with respect to augmentations performed with only 100% Bio-Oss®. For ridge augmentations, no such difference could be detected with the present evaluation. Interestingly, it could be shown that the bone formation is lowest for the the age group between 50 and 60 years. However, there was no difference between the genders, indicating that men also exhibit worse bone formation during what is considered the menopause for women. There was no difference for the new bone formation between smokers and non-smokers, however, this could be due to the smokers being generally excluded from most studies. Consequently, only 20 specimen from smokers were found in the literature. The here presented work can give new insight into the identification of risk factors, and into the kinetics of bone formation, after bone grafting with Bio-Oss® with and without addition of autogenous bone. This can lead to a more scientifically based treatment concept -clinical timing and biomaterials used - avoiding potential problems.

References

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  • Artzi COIR 2002;
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This Poster was submitted by Dr. Dominikus Lysek.

Correspondence address:
Dr. Dominikus Lysek
Geistlich Pharma AG
Bahnhofstrasse 40
6110 Wolhusen
Switzerland