Int Poster J Dent Oral Med 17 (2015), No. 4 15. Dec. 2015
Int Poster J Dent Oral Med 17 (2015), No. 4 (15.12.2015)
Poster 933, Language: English
Adjunctive Antimicrobial Photodynamic Therapy in Chronic Periodontitis Treatment - A Meta-Analysis
Müller, Friedrich / Müller, Janine / Noack, Barbara / Hoffmann, Thomas
Aim: To investigate the efficacy of adjunctive antimicrobial photodynamic therapy (aPDT) in patients with chronic periodontitis.
Material and Methods: Meta-analyses were conducted according to PRISMA and Cochrane recommendations. Extensive literature and manual search were performed on eight databases. Mean difference (MD), 95% confidence intervals (CI) were calculated for probing depth (PD) reduction and gain in attachment level (AL). I2 test was used for inter-study heterogeneity, publication bias was examined by visual inspection of funnel plots.
Results: From 992 identified and available records 811 were screened after removing of duplicates. 143 full-text reports were assessed and 81 studies were included in qualitative and 12 in quantitative synthesis (meta-analysis). The metaanalysis showed a statistical significant superior PD reduction (mm) and AL gain (mm) in test group (SRP + aPDT)
over control group (SRP alone) for the follow-up of:
6 weeks (PD reduction) MD 0.15, 95% CI 0.06 to 0.25, p=0.001;
12 weeks (PD reduction) MD 0.17, 95% CI 0.16 to 0.18, p<0.00001;
12 weeks (AL gain) MD 0.24, 95% CI 0.10 to 0.38, p=0.007.
For the follow-up of 6 months the meta-analysis showed a not statistical significant difference between test and control
6 months (PD reduction) MD 0.08, 95% CI -0.25 to 0.42, p=0.63;
6 months (AL gain) MD 0.20, 95% CI -0.08 to 0.48, p= 0.16.
Conclusion: While there is strong clinical evidence of short-term benefits for PD reduction (mm) and AL gain (mm) weak evidence is available for long-term benefits of adjunctive antimicrobial photodynamic therapy in chronic periodontitis.
Keywords: adjunctive photodynamic therapy, chronic periodontitis, meta-analysis
03.-06. June 2015