Int Poster J Dent Oral Med 16 (2014), CAMLOG 5. Aug. 2014
Int Poster J Dent Oral Med 16 (2014), CAMLOG (05.08.2014)
Supplement, Poster 791, Language: English
Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws
Holzinger, Daniel / Seemann, Rudolf / Matoni, Nadja / Ewers, Rolf / Millesi, Werner / Wutzl, Arno
Objective: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate therapy. Dental implants are believed to be a risk factor for developing BRONJ. In the present study we analyze the time span of developing BRONJ in patients treated with bisphosphonate and receiving dental implants.
Study design: Patients with dental implants and established BRONJ at the Medical University Clinic of Vienna and studies from 1978 to 2012 were included in a meta-analysis. Three groups were created: a) implantation before bisphosphonate treatment, b) implantation after bisphosphonate treatment, c) implantation during bisphosphonate treatment. Outcomes were evaluated by linear regression analysis.
Results: Patients who underwent dental implantation during (p<0.001) and after treatment with bisphosphonates developed BRONJ more rapidly (p<0.001). The duration of treatment with oral bisphosphonates was significantly related to the rapidity of developing BRONJ (p=0.03).
Conclusion: The insertion of dental implants during or after bisphosphonate treatment accelerates the development of BRONJ. BRONJ occurs less frequently during oral bisphosphonate treatment and dental implantation.
Keywords: BRONJ, Dental Implants, ONJ, Osteomyelitis, Bisphossphonates
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