Int Poster J Dent Oral Med 13 (2011), No. 2 15. June 2011
Int Poster J Dent Oral Med 13 (2011), No. 2 (15.06.2011)
Poster 532, Language: English
Changes of parotid gland function due tosimultaneous radiochemotherapy
Hey, Jeremias / Boeckler, Arne F. / Setz, Jürgen M. / Gerlach, Reinhard / Gernhardt, Christian Ralf / Kuhnt, Thomas
To investigate complication probability on parotid gland tissue due to simultaneous radiochemotherapy [RCHT] with cisplatin, 61 patients treated with radiotherapy [RT] and 36 patients treated with RCHT for head and neck cancer were prospectively evaluated. Stimulated salivary flow rates were measured before, at 4 weeks and 6 months after the treatment. Dose and volume distributions of the parotid glands were recorded.
The dose leading to a complication probability of 50% [TD50] was found to be 32.2Gy/4weeks and 32.1Gy/6months for RCHT and 41.1Gy/4weeks and 39.6Gy/6months for RT. The tolerated dose for RCHT was at least 7-8Gy lower than for RT alone at TD50. It seems that RCHT cause a higher probability of parotid gland tissue damage.
Keywords: radiochemotherapy, salivary flow rate, parotid gland
July 14 - 17, 2010
88th General Session & Exhibition of the IADR Barcelona